Born in 1995 in Cortona (Tuscany), Samuele was European XC champion in the 300 class at the age of just nineteen. After a militancy in the MX2 World Championship, and later in MXGP, Bernardini won the Tricolore Prestige MX1 in 2019.
In 2020, in search of new stimuli, Bernardini decided to switch to Enduro. His debut in Enduro competition was exceptional, with third place in the E1 World Championship – which earned him the title of Rookie of the Year – and third place at the Assoluti d’Italia in the 250 4T. Today, at the age of 29, he is preparing for his fourth season in Enduro- as he will switch to the 300 4-stroke.